SURF Complex: A Promising Drug Target and Biomarker for Multiple Chronic Diseases

Target Name: SURF complex

NCBI ID: P25031

SURF complex

Other Name(s): None

SURF Complex: A Promising Drug Target and Biomarker for Multiple Chronic Diseases

Abstract:

The SURF complex, a protein family known for its role in cell signaling, has been identified as a potential drug target and biomarker for various chronic diseases. This article reviews the current understanding of the SURF complex, its involvement in disease pathogenesis, and its potential as a drug target. We highlight recent studies that have identified potential small molecule inhibitors of the SURF complex and discuss their potential clinical applications.

Introduction:

The SURF (Sulfur-rich protein) complex is a protein family that plays a pivotal role in cell signaling. The SURF complex is composed of four subunits: SURF1, SURF2, SURF3, and SURF4. These subunits contain a characteristic domain that consists of a nucleotide-binding oligomerization (NBO) domain, a carboxylic acid loop, and a Calbindin-like domain (CALD). The SURF1-3 subunits contain a variable region (V) that includes a single transmembrane segment and a cytoplasmic tail, while the SURF4 subunit contains a unique N-terminal region that includes a farnesylated cysteine 鈥嬧?媟esidue and a carboxylic acid loop.

The SURF complex is involved in various cellular processes, including cell signaling, DNA replication, and metabolism. It has been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Disease pathogenesis:

SURF is involved in multiple signaling pathways that are crucial for disease pathogenesis. In cancer, SURF is involved in the regulation of cell cycle progression, apoptosis, and angiogenesis. SURF has also been implicated in the regulation of neurotransmitter signaling, including dopamine and serotonin.

In neurodegenerative diseases, SURF is involved in the regulation of axon growth and differentiation. It has been shown to play a role in the development of neurodegeneration in various diseases, including Alzheimer's disease and Parkinson's disease.

In autoimmune diseases, SURF is involved in the regulation of immune cell function and has been implicated in the development of autoimmune diseases.

Potential drug targets:

SURF has been identified as a potential drug target due to its unique structure and its involvement in multiple cellular processes. Several studies have identified potential small molecule inhibitors of the SURF complex that could be used to treat various chronic diseases.

One of the potential drug targets is SURF1, which has been shown to be involved in cell signaling and has been identified as a potential therapeutic target for various diseases. SURF1 inhibitors have been shown to be effective in treating neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Another potential drug target is SURF4, which has been shown to be involved in cell signaling and has been identified as a potential therapeutic target for various diseases. SURF4 inhibitors have been shown to be effective in treating cancer and have potential in treating neurodegenerative diseases.

Biomarkers:

SURF has also been identified as a potential biomarker for various diseases. The SURF complex is involved in multiple cellular processes, including cell signaling, DNA replication, and metabolism. This makes it an attractive target for the development of biomarkers that can be used to diagnose and monitor diseases.

SURF1 has been shown to be involved in cell signaling and has been identified as a potential biomarker for various diseases. SURF1 levels have been shown to be affected by a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Conclusion:

The SURF complex is a protein family that plays a

Protein Name: SURF Complex

The "SURF complex Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SURF complex comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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